Acylation
Attachment of a fatty-acid chain to a side chain, conferring albumin binding and a long half-life. The defining modification of the long-acting GLP-1 analogues.
Related terms
- AEEA linker
- 2-(2-(2-aminoethoxy)ethoxy)acetic acid. The spacer between the peptide backbone and the fatty-acid chain in semaglutide. Its loss gives the diagnostic −145 Da impurity.
see also Acylation
Where this term appears
The glossary exists to make record pages readable without a chemistry degree. Every technical term on a report resolves here.
- Assay report records — the term appears in result tables, peak tables and provenance blocks
- Method references — where the measurement behind the term is defined
- All 17 glossary terms beginning with A