Terms beginning with L
9 of 238 glossary terms.
- Lock mass
- A reference compound infused continuously so calibration drift can be corrected in real time. Its absence limits mass accuracy to the last external calibration.
- Label claim
- The mass of compound stated on the vial. Whether it refers to gross fill or to peptide content is almost never specified.
- Lactam bridge
- A cyclisation through an amide bond between a side-chain carboxyl and a side-chain amine. Melanotan II and bremelanotide are lactam-cyclised.
- Lyophilisation
- Freeze-drying: freezing the solution then subliming the ice under vacuum. Cake structure and residual moisture are the observable outputs.
- LAL
- Limulus amebocyte lysate. The horseshoe-crab-derived reagent whose clotting cascade detects endotoxin. Available as gel-clot, turbidimetric and chromogenic assays.
- Limits of agreement
- Mean difference ± 1.96 standard deviations of the difference. The interval within which 95 % of paired differences fall.
- Linearity
- Proportionality of detector response to concentration across the working range. Required for an assay; irrelevant to area percent.
- Limit of detection (LOD)
- The lowest amount detectable, conventionally at a signal-to-noise ratio of 3.
- Limit of quantitation (LOQ)
- The lowest amount quantifiable with acceptable precision, conventionally S/N ≥ 10 with RSD ≤ 10 %.
see also Mass accuracy
see also Recovered mass · Rule AX-R06
see also Macrolactamisation
see also Collapse temperature · Residual moisture
see also Gel-clot · Kinetic chromogenic
see also Bland–Altman analysis
see also Validation · Range
see also Limit of quantitation (LOQ)
see also Limit of detection (LOD)