Freeze–thaw
Repeated freezing and thawing of a reconstituted solution. A common aggregation trigger and a standard forced-degradation stress.
Related terms
- Aggregate
- A non-covalent assembly of two or more molecules. Dissociated by the acidic organic mobile phase of reverse-phase HPLC, so invisible to it. Seen by size-exclusion chromatography.
- Forced degradation
- Deliberately stressing a sample under acid, base, oxidative, thermal and photolytic conditions to prove the method can resolve degradants.
see also Fibrillation
see also Stability-indicating method
Where this term appears
The glossary exists to make record pages readable without a chemistry degree. Every technical term on a report resolves here.
- Assay report records — the term appears in result tables, peak tables and provenance blocks
- Method references — where the measurement behind the term is defined
- All 5 glossary terms beginning with F