AssayIndex

WXT-2505-M3910

5-Amino-1MQ · 100 mg declared · WuXi TIDES (WuXi AppTec Testing Division) · manufactured 04 May 2025

CHARACTERISED
Lot code
WXT-2505-M3910
Supplier
WXT — WuXi TIDES (WuXi AppTec Testing Division)
Compound
5-Amino-1MQ
Compound class
Non-peptide adjuncts
Declared label claim
100mg
Manufacture date
04 May 2025
Index quarter
2025-Q2
Independent assays
10
Laboratories involved
VendorInvestigate, Janoshik, Medutest, Nordanalyt, Kestrel
Provenance mix
Buyer-sourced ×4 · Supplier-supplied ×5 · Laboratory-retained ×1
Section 1

Reproducibility across independent tests

Every report below is an observation of the same physical material. What they disagree about is measurement; what they agree about is the lot. The size of the disagreement is compared against what the contributing laboratories' own repeatability figures predict.

Independent assays 10
Median purity 98.51% n=10
Spread (max − min) 0.87pp n=10
Standard deviation 0.317pp n=10
97.898.298.698.999.399.7100.1This lot (WXT-2505-M3910)This lot (WXT-2505-M3910): Q1 98.11, median 98.50, Q3 98.61, n=10n=10All 5-Amino-1MQAll 5-Amino-1MQ: Q1 98.87, median 99.24, Q3 99.56, n=68n=68 Purity (% area)
Figure 1. This lot's independent purity results against the whole 5-Amino-1MQ record set in the index. The vertical line is the index acceptance specification for the non-peptide adjuncts class, 98.0 % area. A narrow box on the top row against a wide box on the bottom row is the ideal reading: it means the disagreement between lots is much larger than the disagreement within this one.
Section 2

Member reports 10

Every report the index holds on this lot. Each is a page carrying its own chromatogram, mass spectrum, mass balance, provenance and caveats.

ReportLotLabQuarterPurity %Water %Recovery %ProvenanceFlagsResult
AX-2025-021014WXT-2505-M3910VendorInvestigate2025-Q297.953.13105.5Buyer-sourced1FAIL
AX-2025-021015WXT-2505-M3910Janoshik2025-Q298.612.77Supplier-supplied1FAIL
AX-2025-021016WXT-2505-M3910Janoshik2025-Q298.432.83Buyer-sourced1FAIL
AX-2025-021017WXT-2505-M3910Medutest2025-Q298.612.51Supplier-supplied1FAIL
AX-2025-021018WXT-2505-M3910Medutest2025-Q298.292.58Buyer-sourced1FAIL
AX-2025-021019WXT-2505-M3910Janoshik2025-Q298.722.74Supplier-supplied1FAIL
AX-2025-021020WXT-2505-M3910Nordanalyt2025-Q298.582.88Supplier-supplied1FAIL
AX-2025-021021WXT-2505-M3910Janoshik2025-Q298.052.9590.6Buyer-sourced2FAIL
AX-2025-021022WXT-2505-M3910Janoshik2025-Q297.992.71100.3Laboratory-retained1FAIL
AX-2025-021023WXT-2505-M3910Kestrel2025-Q298.822.93107.5Supplier-supplied1FAIL
Section 3

By laboratory

Where more than one laboratory assayed this lot, the difference between them is a paired observation of their relative bias — the same material, the same time window, different instruments. Those pairs are what the index's bias estimates are built from.

LaboratoryReportsPurity results (% area)MedianGradientPublished bias (pp)Bias-adjusted
VendorInvestigate197.9597.9532min-0.1198.06
Janoshik598.61, 98.43, 98.72, 98.05, 97.9998.4330min+0.0098.43
Medutest298.61, 98.2998.4525min+0.0898.37
Nordanalyt198.5898.5835min+0.0298.56
Kestrel198.8298.8215min+0.2498.58

This lot contributes 10 paired comparisons to the inter-lab analysis.

Section 4

The supplier's certificate for this lot

One number the supplier wrote, beside the median of the numbers other people measured on the same physical material. That comparison is only available because the index groups by lot.

FigureSupplier COAThis reportIndex note
Purity (% area)98.6597.95divergence +0.14 pp vs batch median
Total impurities (% area)1.352.05
Largest single impurity (% area)not stated1.29
Water (%)1.43.13
Counter-ion (%)not stated46.07
Peptide content (%w/w)not stated50.33
Endotoxin (EU/mg)not statednot determined
Method stated on certificateNOno method section — the result cannot be reconciled against any other
Section 5

Impurity fingerprint

The named impurities reported across this lot's assays, with how consistently each was seen. A fingerprint is what allows two lot numbers held by different companies to be identified as one bulk.

Named impurityReported inMedian % areaRange
5-nitro-1MQ (unreduced precursor, +30 Da)10 / 100.500.06–1.29
1-methylquinolinium (des-amino, −15 Da)10 / 100.590.24–1.40
8-amino regioisomer10 / 100.220.19–0.31
free iodide (counter-ion, by IC)10 / 100.100.09–0.14
Section 7

What this rollup does not establish