5-Amino-1MQ impurity profile
Every named species the index has reported alongside 5-Amino-1MQ, how often, at what level, and what its presence implies about the synthesis or the handling. Reporting threshold is 0.05 % area; anything below it is invisible to this page and is silently added to the main peak.
Median total impurities
0.76%
n=68
Median largest single
0.36%
n=68
Worst single observed
1.40%
n=68
Named species observed
4 / 4
n=4
| Named species | ΔRT (min) | Δ mass (Da) | Seen in | Median % area | Max % area |
|---|---|---|---|---|---|
| 5-nitro-1MQ (unreduced precursor, +30 Da) | +0.68 | +29.974 | 96% | 0.09 | 1.29 |
| 8-amino regioisomer | +0.22 | mass-identical | 93% | 0.13 | 0.67 |
| free iodide (counter-ion, by IC) | 0.00 | mass-identical | 93% | 0.13 | 0.56 |
| 1-methylquinolinium (des-amino, −15 Da) | -0.32 | -15.011 | 91% | 0.17 | 1.40 |
5-nitro-1MQ (unreduced precursor, +30 Da)
- Retention offset from the main peak
- +0.68 min on RG-2
- Mass difference
- +29.974 Da
- Reported in
- 65 of 68 records (96 %)
- Level when reported
- median 0.09 %, max 1.29 %
- Resolution requirement
- Baseline-resolved on the reference method.
8-amino regioisomer
- Retention offset from the main peak
- +0.22 min on RG-2
- Mass difference
- mass-identical — chromatography only
- Reported in
- 63 of 68 records (93 %)
- Level when reported
- median 0.13 %, max 0.67 %
- Resolution requirement
- A gradient long enough to separate it. No mass spectrometer will.
free iodide (counter-ion, by IC)
- Retention offset from the main peak
- 0.00 min on RG-2
- Mass difference
- mass-identical — chromatography only
- Reported in
- 63 of 68 records (93 %)
- Level when reported
- median 0.13 %, max 0.56 %
- Resolution requirement
- A gradient long enough to separate it. No mass spectrometer will.
1-methylquinolinium (des-amino, −15 Da)
- Retention offset from the main peak
- -0.32 min on RG-2
- Mass difference
- -15.011 Da
- Reported in
- 62 of 68 records (91 %)
- Level when reported
- median 0.17 %, max 1.40 %
- Resolution requirement
- Baseline-resolved on the reference method.
Degradation pathways
Degradants are a handling finding rather than a synthesis finding. A lot that shipped clean and arrived oxidised tells you about the courier, not the chemist.
- photodegradation of the quinolinium core
- iodide oxidation to iodine on light exposure — visible browning