AX-2025-018595 · GHRP-2 · QYB lot QYB-2510-D4955

Section 1

Results

Measured against the index acceptance specification for the growth-hormone axis peptides class. A specification is a decision the index made; a result is a measurement. See where each threshold came from.

Parameter	Method	Result	Unit	Index spec
Purity	RP-HPLC, 35 min gradient, 214 nm	99.26	% area	≥ 99.0	PASS
Total impurities	RP-HPLC, sum of reported peaks	0.74	% area	≤ 1.0	PASS
Largest single impurity	RP-HPLC — oxidised Trp (+16 Da)	0.29	% area	≤ 1.00	PASS
Identity — theoretical monoisotopic mass	calculated from molecular formula	817.4275	Da	—	NOT TESTED
Identity — observed monoisotopic mass	LC-MS, high resolution (ESI-TOF/QTOF)	817.4257	Da	—	NOT TESTED
Mass accuracy	observed vs theoretical	-2.2	ppm	± 15	PASS
Total peptide content	by difference from the gravimetric mass balance	88.63	%w/w	—	NOT TESTED
Target-compound content	total peptide content × purity	87.97	%w/w	—	NOT TESTED
Gross fill (as weighed)	five-place balance, under nitrogen	5.67	mg	5 mg declared	NOT TESTED
Recovered target peptide	gross fill × target content	4.988	mg	5 mg claim	NOT TESTED
Recovery against label claim	recovered ÷ claim	99.8	%	90.0 – 110.0	PASS
Water content	Karl Fischer, coulometric, duplicate	4.00	%	≤ 9.0	PASS
Counter-ion (acetate)	anion-exchange ion chromatography	6.71	%	≤ 12.0	PASS
Residual solvent + inorganic residue	estimated — see /methods/residual-solvents-q3c/	0.66	%	—	NOT TESTED
Endotoxin	kinetic chromogenic LAL	14.39	EU/mg	≤ 5.0	FAIL
Sterility	not ordered on this submission	not determined	—	no growth	NOT TESTED
Appearance	visual, diffuse light, black and white background	White lyophilised cake, intact	—	white to off-white intact cake	PASS
Reconstitution clarity	reconstituted per submitter procedure	Clear, colourless, no visible particulates	—	clear, no visible particulates	PASS
pH (reconstituted, 1 mg/mL)	potentiometric, two-point calibration	5.11	—	2.5 – 8.0	PASS
Retention time (observed)	RP-HPLC, 35 min gradient	10.40	min	10.45 ± 0.25 (normalised)	PASS
Peak asymmetry (10 % height)	Ph. Eur. 2.2.46	1.25	—	0.80 – 1.50	PASS
Plate count, main peak	N = 5.54 (t/w½)²	59,706	—	≥ 20,000	PASS
Resolution to nearest impurity	vs [D-2-Nal]-epimer	0.94	—	no index criterion	REPORTED

Section 2

Chromatogram and peak integration

The figure is drawn from the table. It is not an independent illustration — if a number in the table changed, the trace would change with it.

Figure 1. RP-HPLC trace, 35 min gradient, 214 nm. Drawn from the peak-integration table below: peak positions are the reported retention times, peak areas are the reported area percentages, peak widths follow the reported plate count of 59,706, and skew follows the reported asymmetry factor of 1.25. Baseline noise is seeded from the report ID and is illustrative. The lower panel is the same trace at a stated vertical expansion with the slow gradient drift subtracted, because at full scale a 0.29 % impurity against a 99.26 % main peak is a line two pixels tall; the main peak runs off-scale there by design.

#	Peak	RT	Area (µV·s)	% area	Δ mass (Da)
1	GHRP-2 — main peak	10.40	4,824,344	99.26	—
2	oxidised Trp (+16 Da)	9.98	14,095	0.29	+15.995
3	C-terminal free acid (+1 Da)	10.59	10,693	0.22	+0.984
4	[D-2-Nal]-epimer	10.24	6,804	0.14	0.000
5	des-Lys (−128 Da)	10.12	4,374	0.09	-128.095
Closure check — purity + Σ impurities				100.00	CLOSES

Reporting threshold 0.05 % area. Peaks below it are not reported and are therefore excluded from the total, which overstates purity by their sum — see peak integration.

Section 3

Mass spectrum and identity

Theoretical monoisotopic mass 817.4275 Da, computed from C45H55N9O6. All ppm figures on this site are against monoisotopic values — see why that matters.

Figure 2. ESI charge-state envelope, high-resolution instrument. Sticks are placed at m/z = (M + z × 1.007276)/z for the observed neutral mass of 817.4257 Da. Sodium (+21.982/z) and potassium (+37.956/z) adducts are shown where the parent charge state exceeds 25 % relative abundance; they are adducts of the same molecule and are not impurities.

Charge	Theoretical m/z	Observed m/z	Δ m/z	Rel. abundance (%)
2+	409.7210	409.7201	-0.0009	54.1
1+	818.4348	818.4330	-0.0018	100.0

Section 4

Gravimetric mass balance

Water, counter-ion, residual and total peptide content are exhaustive and mutually exclusive categories. They must account for 100 % of the cake mass. The index closes this to within 0.02 pp and the build asserts it.

Component	Determination	%w/w of cake
Water	Karl Fischer	4.00
Counter-ion (acetate)	ion chromatography	6.71
Residual solvent + inorganic residue	estimated	0.66
Total peptide content	by difference	88.63
Total		100.00 CLOSES

Supplier certificate, as declared

The supplier's own figures for this lot, beside the independent measurement. Divergence is assessed against the batch median, not against this single report — see rule AX-R05.

Figure	Supplier COA	This report	Index note
Purity (% area)	99.80	99.26	divergence +0.54 pp vs batch median
Total impurities (% area)	0.20	0.74
Largest single impurity (% area)	not stated	0.29
Water (%)	3.3	4.00
Counter-ion (%)	not stated	6.71
Peptide content (%w/w)	not stated	88.63
Endotoxin (EU/mg)	not stated	14.39
Method stated on certificate	NO	—	no method section — the result cannot be reconciled against any other

Section 5

Provenance and caveats

Where a sample came from changes the weight of the evidence. The index treats it as a first-class field.

Sample provenance: Supplier-supplied
Evidentiary weight: Weaker evidence. Read with the caveat below.
Chain of custody: Supplier despatch → laboratory direct (courier, cold pack, 2 d) → assay. Submitter did not handle the vial.
Assay date: 30 Oct 2025
Submitted to the index: 13 Nov 2025
Laboratory: Nordanalyt Laboratories, Uppsala, Sweden
Method basis: 35 min gradient · high-resolution MS
Verification status: VERIFIED

What this report does not establish

That the material is sterile. Sterility was not tested.
That any other vial in the same lot has the same composition. One vial was tested. Within-lot vial-to-vial variation in this index has a median of 0.28 pp and a 90th percentile of 0.74 pp.
That any other lot from the same supplier has the same composition. Batch-to-batch variation is larger than within-batch variation for every supplier here.
That the material is suitable for administration to a human or an animal. These are research compounds. No result on this site is a safety assessment and the index takes no position on use.
That the material was manufactured by the supplier that sold it. Contract synthesis is normal in this market and twenty-nine batches in the index fingerprint to a bulk from a different company than the one named on the label.

Section 6

Annotations 5

Signed technical comments from index contributors. Not a discussion forum — annotations question or contextualise the result, and the data team replies where a reply is warranted.

scale_up_delta13 Nov 2025

14.39 EU/mg but the material was passed through a sterile sterile filter. Some filters leach endotoxins; the measurement does not distinguish material from filter contribution.

underfill_3to113 Nov 2025

Endotoxin tested twice on this lot with varying EU/mg spread. Endotoxin variability in retained samples is larger than most labs acknowledge and the single measurement here is not definitive.

sig_figs13 Nov 2025

Endotoxin undetectable means below the detection limit of on Nordanalyt's system. That does not mean zero and may not reflect actual endotoxin. The cutoff is useful for screening; the absence of a number is not a guarantee.

dispute_log13 Nov 2025

Purity 99.26 % and endotoxin 14.39 EU/mg are unrelated — purity measures synthesis quality, endotoxin measures fill-step water quality. The combination here is coherent and expected together.

Contributor #L-440913 Nov 2025

Endotoxin assay but no bacterial viability or total count. The two are independent: dead endotoxin-bearing bacteria contribute to the burden, living ones that produce endotoxins do not.

Section 7

Related records

Same batch — lot QYB-2510-D4955 n=13

Report	Lot	Lab	Quarter	Purity %	Water %	Recovery %	Provenance	Flags	Result
AX-2025-018589	QYB-2510-D4955	Janoshik	2025-Q4	99.49	4.03	94.3	Supplier-supplied	1	MARGINAL
AX-2025-018590	QYB-2510-D4955	Janoshik	2025-Q4	99.02	4.12	88.7	Supplier-supplied	2	MARGINAL
AX-2025-018591	QYB-2510-D4955	Medutest	2025-Q4	99.52	4.55	—	Supplier-supplied	1	MARGINAL
AX-2025-018592	QYB-2510-D4955	Kestrel	2025-Q4	99.06	3.78	88.7	Supplier-supplied	2	MARGINAL
AX-2025-018593	QYB-2510-D4955	Janoshik	2025-Q4	99.14	4.22	88.8	Supplier-supplied	2	MARGINAL
AX-2025-018594	QYB-2510-D4955	Janoshik	2025-Q4	99.51	5.10	101.0	Supplier-supplied	2	FAIL
AX-2025-018596	QYB-2510-D4955	Janoshik	2025-Q4	98.76	4.53	106.7	Supplier-supplied	1	FAIL
AX-2025-018597	QYB-2510-D4955	Janoshik	2025-Q4	99.17	4.43	95.3	Supplier-supplied	1	MARGINAL
AX-2025-018598	QYB-2510-D4955	Janoshik	2025-Q4	99.04	4.33	—	Supplier-supplied	2	FAIL
AX-2025-018599	QYB-2510-D4955	Janoshik	2025-Q4	99.73	4.39	—	Supplier-supplied	1	MARGINAL
AX-2025-018600	QYB-2510-D4955	Medutest	2025-Q4	99.65	4.83	93.4	Supplier-supplied	1	MARGINAL
AX-2025-018601	QYB-2510-D4955	Medutest	2025-Q4	99.36	4.05	91.5	Supplier-supplied	1	MARGINAL

Batch rollup and reproducibility assessment →

Cross-sections

Other recent GHRP-2 records in the index.
Report	Supplier	Lot	Lab	Quarter	Purity %	Water %	Recovery %	Provenance	Flags	Result
AX-2026-042161	Homopeptide	HOMO-2602-E9033	Medutest	2026-Q2	99.93	3.99	105.6	Supplier-supplied	1	MARGINAL
AX-2026-042302	HJ	HJ-2602-W3148	PeptideMeter	2026-Q2	99.55	1.32	104.9	Supplier-supplied	1	MARGINAL
AX-2026-042159	Homopeptide	HOMO-2602-E9033	Janoshik	2026-Q2	99.39	3.77	—	Laboratory-retained	1	MARGINAL
AX-2026-042303	HJ	HJ-2602-W3148	PeptideMeter	2026-Q2	99.12	1.24	98.0	Supplier-supplied	1	MARGINAL
AX-2026-042160	Homopeptide	HOMO-2602-E9033	Medutest	2026-Q2	99.62	4.50	99.5	Supplier-supplied	1	MARGINAL
AX-2026-043489	WXT	WXT-2605-U5824	PeptideMeter	2026-Q2	98.83	5.76	96.6	Supplier-supplied	2	FAIL
AX-2026-042157	Homopeptide	HOMO-2602-E9033	PeptideMeter	2026-Q2	99.93	4.32	—	Supplier-supplied	1	MARGINAL
AX-2026-042158	Homopeptide	HOMO-2602-E9033	Janoshik	2026-Q2	99.59	4.35	89.8	Buyer-sourced	2	MARGINAL

Other recent QYB records in the index.
Report	Compound	Lot	Lab	Quarter	Purity %	Water %	Recovery %	Provenance	Flags	Result
AX-2026-041453	Retatrutide	QYB-2604-B5660	VendorInvestigate	2026-Q3	98.02	2.55	—	Buyer-sourced	1	MARGINAL
AX-2026-041454	Retatrutide	QYB-2604-B5660	Janoshik	2026-Q3	98.84	2.77	—	Supplier-supplied	1	MARGINAL
AX-2026-041538	Retatrutide	QYB-2602-G6308	Medutest	2026-Q3	98.50	2.85	—	Supplier-supplied	2	MARGINAL
AX-2026-041456	Retatrutide	QYB-2604-B5660	Janoshik	2026-Q3	98.23	3.24	—	Supplier-supplied	1	MARGINAL
AX-2026-041452	Retatrutide	QYB-2604-B5660	Nordanalyt	2026-Q3	98.50	3.36	—	Supplier-supplied	1	MARGINAL
AX-2026-041427	Ipamorelin	QYB-2605-H4298	Janoshik	2026-Q3	99.93	4.12	—	Supplier-supplied	0	PASS
AX-2026-041488	PT-141 (Bremelanotide)	QYB-2607-L5615	Janoshik	2026-Q3	99.93	3.79	—	Supplier-supplied	0	PASS
AX-2026-041459	Retatrutide	QYB-2604-B5660	VendorInvestigate	2026-Q3	97.91	2.84	92.2	Buyer-sourced	1	MARGINAL