Cross-section

SS-31 (Elamipretide) by laboratory

The same compound measured by different laboratories on different gradients. Where the medians differ, the question is whether the material differed or the method did — and for SS-31 (Elamipretide), with a class minimum gradient of 15 min, the method is a live explanation.

97 recordsmedian 99.42 %spec 98.5 %

Laboratory	Reports	Gradient	MS resolution	Median purity %	Published bias (pp)	Bias-adjusted	Method suitability
Janoshik	48	30min	High	99.48	+0.00	99.48	ADEQUATE
PeptideMeter	19	28min	High	99.61	-0.05	99.66	ADEQUATE
Medutest	15	25min	Unit	98.98	+0.08	98.90	ADEQUATE
VendorInvestigate	7 n=7	32min	High	98.87	-0.11	98.98	ADEQUATE
Kestrel	5 n=5	15min	Unit	99.03	+0.24	98.79	ADEQUATE
Nordanalyt	3 n=3	35min	High	99.93	+0.02	99.91	ADEQUATE

Figure. SS-31 (Elamipretide) purity by contributing laboratory. Any offset between rows has two possible sources — a real difference in the material each laboratory happened to receive, and the laboratory's own bias — and this figure cannot separate them. The paired analysis that can is on inter-lab agreement.