Cross-section

MOTS-c by laboratory

The same compound measured by different laboratories on different gradients. Where the medians differ, the question is whether the material differed or the method did — and for MOTS-c, with a class minimum gradient of 15 min, the method is a live explanation.

112 recordsmedian 99.18 %spec 98.0 %

Laboratory	Reports	Gradient	MS resolution	Median purity %	Published bias (pp)	Bias-adjusted	Method suitability
Janoshik	56	30min	High	99.18	+0.00	99.18	ADEQUATE
PeptideMeter	20	28min	High	99.30	-0.05	99.34	ADEQUATE
Medutest	17	25min	Unit	99.18	+0.08	99.10	ADEQUATE
Kestrel	9	15min	Unit	99.37	+0.24	99.13	ADEQUATE
VendorInvestigate	7 n=7	32min	High	98.58	-0.11	98.69	ADEQUATE
Nordanalyt	3 n=3	35min	High	98.07	+0.02	98.05	ADEQUATE

Figure. MOTS-c purity by contributing laboratory. Any offset between rows has two possible sources — a real difference in the material each laboratory happened to receive, and the laboratory's own bias — and this figure cannot separate them. The paired analysis that can is on inter-lab agreement.