Cross-section

Cagrilintide by laboratory

The same compound measured by different laboratories on different gradients. Where the medians differ, the question is whether the material differed or the method did — and for Cagrilintide, with a class minimum gradient of 25 min, the method is a live explanation.

32 recordsmedian 98.59 %spec 96.5 %

Laboratory	Reports	Gradient	MS resolution	Median purity %	Published bias (pp)	Bias-adjusted	Method suitability
Janoshik	16	30min	High	98.16	+0.00	98.16	ADEQUATE
Medutest	7 n=7	25min	Unit	98.58	+0.08	98.50	ADEQUATE
PeptideMeter	4 n=4	28min	High	99.03	-0.05	99.08	ADEQUATE
Nordanalyt	3 n=3	35min	High	99.19	+0.02	99.17	ADEQUATE
Kestrel	2 n=2	15min	Unit	99.28, 99.91	+0.24	—	BELOW CLASS MINIMUM
VendorInvestigate	0	32min	High	—	-0.11	—	ADEQUATE

Figure. Cagrilintide purity by contributing laboratory. Any offset between rows has two possible sources — a real difference in the material each laboratory happened to receive, and the laboratory's own bias — and this figure cannot separate them. The paired analysis that can is on inter-lab agreement.