AX-2026-042854
Retatrutide · 30 mg declared · Nantong Guangyuan Chemical Co., Ltd. · lot GGPE-2601-C2423
MARGINALPURITY ONLY
- Report ID
- AX-2026-042854
- Compound
- Retatrutide
- Compound class
- Incretin analogues and co-agonists
- Supplier
- GGPeps — Nantong Guangyuan Chemical Co., Ltd.
- Batch / lot
- GGPE-2601-C2423
- Declared label claim
- 30mg
- Laboratory
- PeptideMeter
- Assay date
- 06 May 2026
- Submitted
- 24 May 2026
- Quarter
- 2026-Q2
- Submitter
- a.petrescu
- Sample provenance
- Buyer-sourced
Section 1
Results
Measured against the index acceptance specification for the incretin analogues and co-agonists class. A specification is a decision the index made; a result is a measurement. See where each threshold came from.
| Parameter | Method | Result | Unit | Index spec | |
|---|---|---|---|---|---|
| Purity | RP-HPLC, 28 min gradient, 214 nm | 97.52 | % area | ≥ 96.5 | PASS |
| Total impurities | RP-HPLC, sum of reported peaks | 2.48 | % area | ≤ 3.5 | PASS |
| Largest single impurity | RP-HPLC — des-Aib20 analogue | 1.00 | % area | ≤ 1.00 | PASS |
| Identity | not ordered on this submission | not determined | — | required for VERIFIED status | NOT TESTED |
| Total peptide content | by difference from the gravimetric mass balance | 87.12 | %w/w | — | NOT TESTED |
| Target-compound content | total peptide content × purity | 84.96 | %w/w | — | NOT TESTED |
| Gross fill (as weighed) | five-place balance, under nitrogen | 31.33 | mg | 30 mg declared | NOT TESTED |
| Recovered target peptide | gross fill × target content | 26.618 | mg | 30 mg claim | NOT TESTED |
| Recovery against label claim | recovered ÷ claim | 88.7 | % | 90.0 – 110.0 | FAIL |
| Water content | Karl Fischer, coulometric, duplicate | 4.37 | % | ≤ 8.0 | PASS |
| Counter-ion (TFA) | anion-exchange ion chromatography | 8.21 | % | ≤ 12.0 | PASS |
| Residual solvent + inorganic residue | estimated — see /methods/residual-solvents-q3c/ | 0.30 | % | — | NOT TESTED |
| Endotoxin | not ordered on this submission | not determined | — | ≤ 5.0 | NOT TESTED |
| Sterility | not ordered on this submission | not determined | — | no growth | NOT TESTED |
| Appearance | visual, diffuse light, black and white background | White lyophilised cake, intact | — | white to off-white intact cake | PASS |
| Reconstitution clarity | reconstituted per submitter procedure | Clear, colourless, no visible particulates | — | clear, no visible particulates | PASS |
| pH (reconstituted, 1 mg/mL) | potentiometric, two-point calibration | 3.84 | — | 2.5 – 8.0 | PASS |
| Retention time (observed) | RP-HPLC, 28 min gradient | 19.35 | min | 19.44 ± 0.50 (normalised) | PASS |
| Peak asymmetry (10 % height) | Ph. Eur. 2.2.46 | 1.18 | — | 0.80 – 1.50 | PASS |
| Plate count, main peak | N = 5.54 (t/w½)² | 44,425 | — | ≥ 20,000 | PASS |
| Resolution to nearest impurity | vs [D-Aib2]-diastereomer | 0.55 | — | no index criterion | REPORTED |
Section 2
Chromatogram and peak integration
The figure is drawn from the table. It is not an independent illustration — if a number in the table changed, the trace would change with it.
| # | Peak | RT | Area (µV·s) | % area | Δ mass (Da) |
|---|---|---|---|---|---|
| 1 | Retatrutide — main peak | 19.35 | 4,739,774 | 97.52 | — |
| 2 | des-Aib20 analogue | 18.94 | 48,603 | 1.00 | -85.053 |
| 3 | [D-Aib2]-diastereomer | 19.14 | 38,882 | 0.80 | 0.000 |
| 4 | C18 diacid regioisomer | 19.89 | 17,011 | 0.35 | 0.000 |
| 5 | incomplete Fmoc removal (+222 Da) | 21.60 | 7,776 | 0.16 | +222.068 |
| 6 | retatrutide dimer | 23.20 | 4,860 | 0.10 | +4728.487 |
| 7 | truncated (5-39) | 17.56 | 3,402 | 0.07 | -428.201 |
| Closure check — purity + Σ impurities | 100.00 | CLOSES | |||
Reporting threshold 0.05 % area. Peaks below it are not reported and are therefore excluded from the total, which overstates purity by their sum — see peak integration.
Section 4
Gravimetric mass balance
Water, counter-ion, residual and total peptide content are exhaustive and mutually exclusive categories. They must account for 100 % of the cake mass. The index closes this to within 0.02 pp and the build asserts it.
| Component | Determination | %w/w of cake |
|---|---|---|
| Water | Karl Fischer | 4.37 |
| Counter-ion (TFA) | ion chromatography | 8.21 |
| Residual solvent + inorganic residue | estimated | 0.30 |
| Total peptide content | by difference | 87.12 |
| Total | 100.00 CLOSES | |
Supplier certificate, as declared
The supplier's own figures for this lot, beside the independent measurement. Divergence is assessed against the batch median, not against this single report — see rule AX-R05.
| Figure | Supplier COA | This report | Index note |
|---|---|---|---|
| Purity (% area) | 98.13 | 97.52 | divergence +0.06 pp vs batch median |
| Total impurities (% area) | 1.87 | 2.48 | |
| Largest single impurity (% area) | not stated | 1.00 | |
| Water (%) | not stated | 4.37 | |
| Counter-ion (%) | not stated | 8.21 | |
| Peptide content (%w/w) | 97.1 | 87.12 | |
| Endotoxin (EU/mg) | not stated | not determined | |
| Method stated on certificate | YES | — | column, gradient and wavelength given |
Section 5
Provenance and caveats
Where a sample came from changes the weight of the evidence. The index treats it as a first-class field.
- Sample provenance
- Buyer-sourced
- Evidentiary weight
- Strongest available evidence in this index.
- Chain of custody
- Retail purchase → submitter (−20 °C, 16 d) → laboratory (courier, dry ice, 3 d) → assay.
- Assay date
- 06 May 2026
- Submitted to the index
- 24 May 2026
- Laboratory
- PeptideMeter, Tallinn, Estonia
- Method basis
- 28 min gradient · high-resolution MS
- Verification status
- PURITY ONLY
Section 6
Annotations
No annotations on this record. Annotations are short signed technical comments from index contributors; see how to contribute.
Section 7
Related records
Same batch — lot GGPE-2601-C2423 n=14
| Report | Lot | Lab | Quarter | Purity % | Water % | Recovery % | Provenance | Flags | Result |
|---|---|---|---|---|---|---|---|---|---|
| AX-2026-042852 | GGPE-2601-C2423 | PeptideMeter | 2026-Q2 | 97.73 | 3.87 | 89.5 | Supplier-supplied | 2 | MARGINAL |
| AX-2026-042853 | GGPE-2601-C2423 | Janoshik | 2026-Q2 | 98.62 | 3.78 | — | Supplier-supplied | 1 | MARGINAL |
| AX-2026-042855 | GGPE-2601-C2423 | Janoshik | 2026-Q2 | 98.08 | 4.35 | — | Supplier-supplied | 1 | MARGINAL |
| AX-2026-042856 | GGPE-2601-C2423 | Kestrel | 2026-Q2 | 98.97 | 4.29 | 89.4 | Supplier-supplied | 2 | MARGINAL |
| AX-2026-042857 | GGPE-2601-C2423 | Kestrel | 2026-Q2 | 97.51 | 4.23 | 106.4 | Supplier-supplied | 1 | MARGINAL |
| AX-2026-042858 | GGPE-2601-C2423 | Janoshik | 2026-Q2 | 98.06 | 4.29 | — | Supplier-supplied | 1 | MARGINAL |
| AX-2026-042859 | GGPE-2601-C2423 | Janoshik | 2026-Q2 | 98.21 | 4.30 | — | Supplier-supplied | 1 | MARGINAL |
| AX-2026-042860 | GGPE-2601-C2423 | Janoshik | 2026-Q2 | 98.50 | 4.84 | 97.5 | Supplier-supplied | 1 | MARGINAL |
| AX-2026-042861 | GGPE-2601-C2423 | Nordanalyt | 2026-Q2 | 97.48 | 4.46 | — | Supplier-supplied | 1 | MARGINAL |
| AX-2026-042862 | GGPE-2601-C2423 | Janoshik | 2026-Q2 | 98.09 | 4.22 | — | Supplier-supplied | 1 | MARGINAL |
| AX-2026-042863 | GGPE-2601-C2423 | Janoshik | 2026-Q2 | 97.64 | 3.96 | — | Supplier-supplied | 2 | MARGINAL |
| AX-2026-042864 | GGPE-2601-C2423 | Janoshik | 2026-Q2 | 97.66 | 4.68 | — | Supplier-supplied | 1 | MARGINAL |
| AX-2026-042865 | GGPE-2601-C2423 | Nordanalyt | 2026-Q2 | 98.07 | 4.54 | — | Supplier-supplied | 1 | MARGINAL |
Cross-sections
| Report | Supplier | Lot | Lab | Quarter | Purity % | Water % | Recovery % | Provenance | Flags | Result |
|---|---|---|---|---|---|---|---|---|---|---|
| AX-2026-043029 | KP | KP-2607-H5219 | Medutest | 2026-Q3 | 95.45 | 5.71 | — | Supplier-supplied | 2 | FAIL |
| AX-2026-043030 | KP | KP-2607-H5219 | Kestrel | 2026-Q3 | 95.97 | 6.95 | 97.1 | Supplier-supplied | 2 | FAIL |
| AX-2026-041453 | QYB | QYB-2604-B5660 | VendorInvestigate | 2026-Q3 | 98.02 | 2.55 | — | Buyer-sourced | 1 | MARGINAL |
| AX-2026-041454 | QYB | QYB-2604-B5660 | Janoshik | 2026-Q3 | 98.84 | 2.77 | — | Supplier-supplied | 1 | MARGINAL |
| AX-2026-041538 | QYB | QYB-2602-G6308 | Medutest | 2026-Q3 | 98.50 | 2.85 | — | Supplier-supplied | 2 | MARGINAL |
| AX-2026-041456 | QYB | QYB-2604-B5660 | Janoshik | 2026-Q3 | 98.23 | 3.24 | — | Supplier-supplied | 1 | MARGINAL |
| AX-2026-041452 | QYB | QYB-2604-B5660 | Nordanalyt | 2026-Q3 | 98.50 | 3.36 | — | Supplier-supplied | 1 | MARGINAL |
| AX-2026-043039 | KP | KP-2607-H5219 | Janoshik | 2026-Q3 | 96.14 | 5.62 | — | Supplier-supplied | 2 | FAIL |
| Report | Compound | Lot | Lab | Quarter | Purity % | Water % | Recovery % | Provenance | Flags | Result |
|---|---|---|---|---|---|---|---|---|---|---|
| AX-2026-042737 | Selank | GGPE-2603-J9708 | Janoshik | 2026-Q3 | 98.40 | 9.14 | 97.4 | Buyer-sourced | 0 | FAIL |
| AX-2026-042804 | Selank | GGPE-2602-G2056 | Janoshik | 2026-Q3 | 98.50 | 7.97 | — | Supplier-supplied | 0 | FAIL |
| AX-2026-042803 | Selank | GGPE-2602-G2056 | Janoshik | 2026-Q3 | 98.48 | 8.01 | — | Laboratory-retained | 1 | FAIL |
| AX-2026-042802 | Selank | GGPE-2602-G2056 | Janoshik | 2026-Q3 | 98.74 | 7.09 | 96.0 | Supplier-supplied | 0 | FAIL |
| AX-2026-042796 | Selank | GGPE-2602-G2056 | Janoshik | 2026-Q3 | 98.26 | 7.56 | 97.5 | Buyer-sourced | 0 | FAIL |
| AX-2026-042648 | Melanotan II | GGPE-2603-P8735 | Janoshik | 2026-Q3 | 99.10 | 6.97 | — | Supplier-supplied | 4 | MARGINAL |
| AX-2026-042797 | Selank | GGPE-2602-G2056 | Medutest | 2026-Q3 | 98.46 | 7.92 | — | Buyer-sourced | 0 | FAIL |
| AX-2026-042669 | CJC-1295 (no DAC) | GGPE-2606-E8495 | Medutest | 2026-Q3 | 98.61 | 4.06 | 95.5 | Supplier-supplied | 0 | PASS |