Cross-section

Survodutide by laboratory

The same compound measured by different laboratories on different gradients. Where the medians differ, the question is whether the material differed or the method did — and for Survodutide, with a class minimum gradient of 25 min, the method is a live explanation.

68 recordsmedian 98.69 %spec 96.5 %

Laboratory	Reports	Gradient	MS resolution	Median purity %	Published bias (pp)	Bias-adjusted	Method suitability
Janoshik	34	30min	High	98.78	+0.00	98.78	ADEQUATE
PeptideMeter	13	28min	High	98.25	-0.05	98.30	ADEQUATE
Medutest	6 n=6	25min	Unit	98.79	+0.08	98.71	ADEQUATE
VendorInvestigate	6 n=6	32min	High	98.53	-0.11	98.64	ADEQUATE
Kestrel	5 n=5	15min	Unit	99.37	+0.24	99.13	BELOW CLASS MINIMUM
Nordanalyt	4 n=4	35min	High	98.09	+0.02	98.07	ADEQUATE

Figure. Survodutide purity by contributing laboratory. Any offset between rows has two possible sources — a real difference in the material each laboratory happened to receive, and the laboratory's own bias — and this figure cannot separate them. The paired analysis that can is on inter-lab agreement.