MK-677 (Ibutamoren mesylate) impurity profile
Every named species the index has reported alongside MK-677 (Ibutamoren mesylate), how often, at what level, and what its presence implies about the synthesis or the handling. Reporting threshold is 0.05 % area; anything below it is invisible to this page and is silently added to the main peak.
Median total impurities
0.64%
n=152
Median largest single
0.36%
n=152
Worst single observed
1.30%
n=152
Named species observed
5 / 5
n=5
| Named species | ΔRT (min) | Δ mass (Da) | Seen in | Median % area | Max % area |
|---|---|---|---|---|---|
| free base (des-mesylate, −96 Da) | +0.04 | -96.011 | 88% | 0.10 | 1.26 |
| sulfonamide hydrolysis product (+18 Da) | -0.86 | +18.011 | 83% | 0.17 | 1.30 |
| spiroindane regioisomer | +0.44 | mass-identical | 82% | 0.10 | 1.28 |
| residual DMF (process solvent) | -8.20 | -551.000 | 79% | 0.08 | 0.44 |
| O-desmethyl metabolite analogue (−14 Da) | -0.52 | -14.016 | 78% | 0.07 | 1.30 |
free base (des-mesylate, −96 Da)
- Retention offset from the main peak
- +0.04 min on RG-2
- Mass difference
- -96.011 Da
- Reported in
- 134 of 152 records (88 %)
- Level when reported
- median 0.10 %, max 1.26 %
- Resolution requirement
- Close-eluting — resolution below 1.2 is common and the peaks merge on short gradients.
sulfonamide hydrolysis product (+18 Da)
- Retention offset from the main peak
- -0.86 min on RG-2
- Mass difference
- +18.011 Da
- Reported in
- 126 of 152 records (83 %)
- Level when reported
- median 0.17 %, max 1.30 %
- Resolution requirement
- Baseline-resolved on the reference method.
spiroindane regioisomer
- Retention offset from the main peak
- +0.44 min on RG-2
- Mass difference
- mass-identical — chromatography only
- Reported in
- 125 of 152 records (82 %)
- Level when reported
- median 0.10 %, max 1.28 %
- Resolution requirement
- A gradient long enough to separate it. No mass spectrometer will.
residual DMF (process solvent)
- Retention offset from the main peak
- -8.20 min on RG-2
- Mass difference
- -551.000 Da
- Reported in
- 120 of 152 records (79 %)
- Level when reported
- median 0.08 %, max 0.44 %
- Resolution requirement
- Baseline-resolved on the reference method.
O-desmethyl metabolite analogue (−14 Da)
- Retention offset from the main peak
- -0.52 min on RG-2
- Mass difference
- -14.016 Da
- Reported in
- 118 of 152 records (78 %)
- Level when reported
- median 0.07 %, max 1.30 %
- Resolution requirement
- Baseline-resolved on the reference method.
Degradation pathways
Degradants are a handling finding rather than a synthesis finding. A lot that shipped clean and arrived oxidised tells you about the courier, not the chemist.
- sulfonamide hydrolysis under strongly basic conditions
- no oxidative or proteolytic liability