Mazdutide impurity profile
Every named species the index has reported alongside Mazdutide, how often, at what level, and what its presence implies about the synthesis or the handling. Reporting threshold is 0.05 % area; anything below it is invisible to this page and is silently added to the main peak.
Median total impurities
1.89%
n=33
Median largest single
0.88%
n=33
Worst single observed
1.63%
n=33
Named species observed
5 / 5
n=5
| Named species | ΔRT (min) | Δ mass (Da) | Seen in | Median % area | Max % area |
|---|---|---|---|---|---|
| [D-Aib2]-diastereomer | -0.21 | mass-identical | 100% | 0.32 | 0.80 |
| des-Aib2 analogue | -0.39 | -85.053 | 100% | 0.27 | 1.63 |
| oxidised Met (+16 Da) | -0.70 | +15.995 | 97% | 0.17 | 1.28 |
| truncated (4-39) | -1.74 | -315.169 | 97% | 0.31 | 1.25 |
| trifluoroacetyl adduct (+96 Da) | +0.90 | +95.982 | 97% | 0.18 | 1.41 |
[D-Aib2]-diastereomer
- Retention offset from the main peak
- -0.21 min on RG-2
- Mass difference
- mass-identical — chromatography only
- Reported in
- 33 of 33 records (100 %)
- Level when reported
- median 0.32 %, max 0.80 %
- Resolution requirement
- A gradient long enough to separate it. No mass spectrometer will.
des-Aib2 analogue
- Retention offset from the main peak
- -0.39 min on RG-2
- Mass difference
- -85.053 Da
- Reported in
- 33 of 33 records (100 %)
- Level when reported
- median 0.27 %, max 1.63 %
- Resolution requirement
- Baseline-resolved on the reference method.
oxidised Met (+16 Da)
- Retention offset from the main peak
- -0.70 min on RG-2
- Mass difference
- +15.995 Da
- Reported in
- 32 of 33 records (97 %)
- Level when reported
- median 0.17 %, max 1.28 %
- Resolution requirement
- Baseline-resolved on the reference method.
truncated (4-39)
- Retention offset from the main peak
- -1.74 min on RG-2
- Mass difference
- -315.169 Da
- Reported in
- 32 of 33 records (97 %)
- Level when reported
- median 0.31 %, max 1.25 %
- Resolution requirement
- Baseline-resolved on the reference method.
trifluoroacetyl adduct (+96 Da)
- Retention offset from the main peak
- +0.90 min on RG-2
- Mass difference
- +95.982 Da
- Reported in
- 32 of 33 records (97 %)
- Level when reported
- median 0.18 %, max 1.41 %
- Resolution requirement
- Baseline-resolved on the reference method.
Degradation pathways
Degradants are a handling finding rather than a synthesis finding. A lot that shipped clean and arrived oxidised tells you about the courier, not the chemist.
- Met oxidation
- lipid-chain hydrolysis under alkaline stress