Cross-section

AOD-9604 by laboratory

The same compound measured by different laboratories on different gradients. Where the medians differ, the question is whether the material differed or the method did — and for AOD-9604, with a class minimum gradient of 15 min, the method is a live explanation.

89 recordsmedian 99.25 %spec 98.0 %

Laboratory	Reports	Gradient	MS resolution	Median purity %	Published bias (pp)	Bias-adjusted	Method suitability
Janoshik	50	30min	High	99.43	+0.00	99.43	ADEQUATE
Medutest	14	25min	Unit	99.13	+0.08	99.05	ADEQUATE
VendorInvestigate	9	32min	High	97.85	-0.11	97.96	ADEQUATE
PeptideMeter	8	28min	High	99.37	-0.05	99.42	ADEQUATE
Nordanalyt	4 n=4	35min	High	99.27	+0.02	99.25	ADEQUATE
Kestrel	4 n=4	15min	Unit	99.93	+0.24	99.69	ADEQUATE

Figure. AOD-9604 purity by contributing laboratory. Any offset between rows has two possible sources — a real difference in the material each laboratory happened to receive, and the laboratory's own bias — and this figure cannot separate them. The paired analysis that can is on inter-lab agreement.