AssayIndex

HOMO-2408-P9247

PT-141 (Bremelanotide) · 10 mg declared · Hunan Aslsen Technology Co., Ltd. · manufactured 16 Aug 2024

CHARACTERISED
Lot code
HOMO-2408-P9247
Supplier
Homopeptide — Hunan Aslsen Technology Co., Ltd.
Compound
PT-141 (Bremelanotide)
Compound class
Melanocortin-receptor peptides
Declared label claim
10mg
Manufacture date
16 Aug 2024
Index quarter
2024-Q4
Independent assays
10
Laboratories involved
VendorInvestigate, Janoshik, Kestrel, Medutest, PeptideMeter
Provenance mix
Buyer-sourced ×2 · Supplier-supplied ×7 · Laboratory-retained ×1
Section 1

Reproducibility across independent tests

Every report below is an observation of the same physical material. What they disagree about is measurement; what they agree about is the lot. The size of the disagreement is compared against what the contributing laboratories' own repeatability figures predict.

Independent assays 10
Median purity 99.67% n=10
Spread (max − min) 1.12pp n=10
Standard deviation 0.359pp n=10
97.497.898.398.899.299.7100.1This lot (HOMO-2408-P9247)This lot (HOMO-2408-P9247): Q1 99.41, median 99.67, Q3 99.90, n=10n=10All PT-141 (Bremelanotide)All PT-141 (Bremelanotide): Q1 98.69, median 99.31, Q3 99.84, n=200n=200 Purity (% area)
Figure 1. This lot's independent purity results against the whole PT-141 (Bremelanotide) record set in the index. The vertical line is the index acceptance specification for the melanocortin-receptor peptides class, 98.5 % area. A narrow box on the top row against a wide box on the bottom row is the ideal reading: it means the disagreement between lots is much larger than the disagreement within this one.
Section 2

Member reports 10

Every report the index holds on this lot. Each is a page carrying its own chromatogram, mass spectrum, mass balance, provenance and caveats.

ReportLotLabQuarterPurity %Water %Recovery %ProvenanceFlagsResult
AX-2024-004746HOMO-2408-P9247VendorInvestigate2024-Q498.812.0690.4Buyer-sourced2MARGINAL
AX-2024-004747HOMO-2408-P9247Janoshik2024-Q499.441.95Buyer-sourced2MARGINAL
AX-2024-004748HOMO-2408-P9247Kestrel2024-Q499.932.09Supplier-supplied2MARGINAL
AX-2024-004749HOMO-2408-P9247Medutest2024-Q499.932.12100.5Supplier-supplied2MARGINAL
AX-2024-004750HOMO-2408-P9247PeptideMeter2024-Q499.801.8599.3Laboratory-retained2MARGINAL
AX-2024-004751HOMO-2408-P9247Janoshik2024-Q499.402.18Supplier-supplied2MARGINAL
AX-2024-004752HOMO-2408-P9247Janoshik2024-Q499.592.10Supplier-supplied2MARGINAL
AX-2024-004753HOMO-2408-P9247Janoshik2024-Q499.312.1795.5Supplier-supplied2MARGINAL
AX-2024-004754HOMO-2408-P9247Janoshik2024-Q499.751.49Supplier-supplied2MARGINAL
AX-2024-004755HOMO-2408-P9247Janoshik2024-Q499.932.44Supplier-supplied2MARGINAL
Section 3

By laboratory

Where more than one laboratory assayed this lot, the difference between them is a paired observation of their relative bias — the same material, the same time window, different instruments. Those pairs are what the index's bias estimates are built from.

LaboratoryReportsPurity results (% area)MedianGradientPublished bias (pp)Bias-adjusted
VendorInvestigate198.8198.8132min-0.1198.92
Janoshik699.44, 99.40, 99.59, 99.31, 99.75, 99.9399.5230min+0.0099.52
Kestrel199.9399.9315min+0.2499.69
Medutest199.9399.9325min+0.0899.85
PeptideMeter199.8099.8028min-0.0599.85

This lot contributes 10 paired comparisons to the inter-lab analysis.

Section 4

The supplier's certificate for this lot

One number the supplier wrote, beside the median of the numbers other people measured on the same physical material. That comparison is only available because the index groups by lot.

FigureSupplier COAThis reportIndex note
Purity (% area)100.098.81divergence +0.33 pp vs batch median
Total impurities (% area)not stated1.19
Largest single impurity (% area)not stated0.67
Water (%)0.42.06
Counter-ion (%)7.94.40
Peptide content (%w/w)97.393.39
Endotoxin (EU/mg)not statednot determined
Method stated on certificateYEScolumn, gradient and wavelength given
Section 5

Impurity fingerprint

The named impurities reported across this lot's assays, with how consistently each was seen. A fingerprint is what allows two lot numbers held by different companies to be identified as one bulk.

Named impurityReported inMedian % areaRange
des-acetyl (−42 Da)10 / 100.180.03–0.67
melanotan II (C-terminal amide, −1 Da)9 / 100.050.03–0.17
linear precursor (+18 Da)8 / 100.080.04–0.23
oxidised Trp (+16 Da)6 / 100.070.03–0.13
Section 7

What this rollup does not establish