CPC-2502-X3345

PT-141 (Bremelanotide) · 10 mg declared · Chinese Peptide Company Co., Ltd. · manufactured 01 Feb 2025

PARTIALLY CHARACTERISEDSHARED BULK

Lot code: CPC-2502-X3345
Supplier: CPC — Chinese Peptide Company Co., Ltd.
Compound: PT-141 (Bremelanotide)
Compound class: Melanocortin-receptor peptides
Declared label claim: 10mg
Manufacture date: 01 Feb 2025
Index quarter: 2025-Q3
Independent assays: 2
Laboratories involved: Janoshik, Kestrel
Provenance mix: Supplier-supplied ×2

Section 1

Reproducibility across independent tests

Every report below is an observation of the same physical material. What they disagree about is measurement; what they agree about is the lot. The size of the disagreement is compared against what the contributing laboratories' own repeatability figures predict.

Independent assays 2

Median purity 98.82% n=2

Spread (max − min) 0.41pp n=2

Standard deviation n<3 n=2

Figure 1. This lot's independent purity results against the whole PT-141 (Bremelanotide) record set in the index. The vertical line is the index acceptance specification for the melanocortin-receptor peptides class, 98.5 % area. A narrow box on the top row against a wide box on the bottom row is the ideal reading: it means the disagreement between lots is much larger than the disagreement within this one.

Section 2

Member reports 2

Every report the index holds on this lot. Each is a page carrying its own chromatogram, mass spectrum, mass balance, provenance and caveats.

Report	Lot	Lab	Quarter	Purity %	Water %	Recovery %	Provenance	Flags	Result
AX-2025-020935	CPC-2502-X3345	Janoshik	2025-Q3	98.61	4.66	—	Supplier-supplied	1	MARGINAL
AX-2025-020936	CPC-2502-X3345	Kestrel	2025-Q3	99.02	5.05	91.6	Supplier-supplied	1	MARGINAL

Section 3

By laboratory

Where more than one laboratory assayed this lot, the difference between them is a paired observation of their relative bias — the same material, the same time window, different instruments. Those pairs are what the index's bias estimates are built from.

Laboratory	Reports	Purity results (% area)	Median	Gradient	Published bias (pp)	Bias-adjusted
Janoshik	1	98.61	98.61	30min	+0.00	98.61
Kestrel	1	99.02	99.02	15min	+0.24	98.78

This lot contributes 1 paired comparison to the inter-lab analysis.

Section 4

The supplier's certificate for this lot

One number the supplier wrote, beside the median of the numbers other people measured on the same physical material. That comparison is only available because the index groups by lot.

Figure	Supplier COA	This report	Index note
Purity (% area)	98.13	98.61	divergence -0.69 pp vs batch median
Total impurities (% area)	1.87	1.39
Largest single impurity (% area)	not stated	0.94
Water (%)	not stated	4.66
Counter-ion (%)	not stated	4.20
Peptide content (%w/w)	not stated	not determined
Endotoxin (EU/mg)	0.37	not determined
Method stated on certificate	NO	—	no method section — the result cannot be reconciled against any other

Section 5

Impurity fingerprint

The named impurities reported across this lot's assays, with how consistently each was seen. A fingerprint is what allows two lot numbers held by different companies to be identified as one bulk.

Named impurity	Reported in	Median % area	Range
melanotan II (C-terminal amide, −1 Da)	2 / 2	0.56	0.19–0.94
des-acetyl (−42 Da)	2 / 2	0.18	0.05–0.31
linear precursor (+18 Da)	2 / 2	0.09	0.07–0.10
oxidised Trp (+16 Da)	2 / 2	0.36	0.07–0.64

Section 6

Shared-bulk links

Rule AX-R09. Where impurity fingerprints and latent composition match across companies, the index treats the material as one bulk and counts it once in aggregates.

Lot	Sold by	Role	Reports	Median purity
GLBI-2511-F8417	GL Biochem	parent bulk	7	97.84
CPC-2502-X3345	CPC	this lot	2	98.82

Section 7