SLU-PP-332 impurity profile
Every named species the index has reported alongside SLU-PP-332, how often, at what level, and what its presence implies about the synthesis or the handling. Reporting threshold is 0.05 % area; anything below it is invisible to this page and is silently added to the main peak.
Median total impurities
1.31%
n=32
Median largest single
0.71%
n=32
Worst single observed
1.19%
n=32
Named species observed
4 / 4
n=4
| Named species | ΔRT (min) | Δ mass (Da) | Seen in | Median % area | Max % area |
|---|---|---|---|---|---|
| hydrolysed ester (+18 Da) | -1.24 | +18.011 | 100% | 0.24 | 0.95 |
| des-methyl analogue (−14 Da) | -0.36 | -14.016 | 100% | 0.15 | 1.19 |
| residual DMSO (process solvent) | -10.10 | mass-identical | 100% | 0.28 | 0.97 |
| sulfoxide (+16 Da) | -0.72 | +15.995 | 97% | 0.26 | 0.68 |
hydrolysed ester (+18 Da)
- Retention offset from the main peak
- -1.24 min on RG-2
- Mass difference
- +18.011 Da
- Reported in
- 32 of 32 records (100 %)
- Level when reported
- median 0.24 %, max 0.95 %
- Resolution requirement
- Baseline-resolved on the reference method.
des-methyl analogue (−14 Da)
- Retention offset from the main peak
- -0.36 min on RG-2
- Mass difference
- -14.016 Da
- Reported in
- 32 of 32 records (100 %)
- Level when reported
- median 0.15 %, max 1.19 %
- Resolution requirement
- Baseline-resolved on the reference method.
residual DMSO (process solvent)
- Retention offset from the main peak
- -10.10 min on RG-2
- Mass difference
- mass-identical — chromatography only
- Reported in
- 32 of 32 records (100 %)
- Level when reported
- median 0.28 %, max 0.97 %
- Resolution requirement
- A gradient long enough to separate it. No mass spectrometer will.
sulfoxide (+16 Da)
- Retention offset from the main peak
- -0.72 min on RG-2
- Mass difference
- +15.995 Da
- Reported in
- 31 of 32 records (97 %)
- Level when reported
- median 0.26 %, max 0.68 %
- Resolution requirement
- Baseline-resolved on the reference method.
Degradation pathways
Degradants are a handling finding rather than a synthesis finding. A lot that shipped clean and arrived oxidised tells you about the courier, not the chemist.
- ester hydrolysis in aqueous suspension
- thioether oxidation