CJC-1295 with DAC impurity profile
Every named species the index has reported alongside CJC-1295 with DAC, how often, at what level, and what its presence implies about the synthesis or the handling. Reporting threshold is 0.05 % area; anything below it is invisible to this page and is silently added to the main peak.
Median total impurities
1.21%
n=136
Median largest single
0.59%
n=136
Worst single observed
2.10%
n=136
Named species observed
4 / 4
n=4
| Named species | ΔRT (min) | Δ mass (Da) | Seen in | Median % area | Max % area |
|---|---|---|---|---|---|
| hydrolysed maleimide (+18 Da) | -0.62 | +18.011 | 99% | 0.35 | 2.10 |
| maleimide dimer | +2.42 | +3644.975 | 96% | 0.15 | 1.71 |
| mod-GRF (1-29) (−279 Da) | -1.76 | -279.235 | 94% | 0.23 | 1.38 |
| deamidated (+1 Da) | -0.26 | +0.984 | 93% | 0.16 | 1.53 |
hydrolysed maleimide (+18 Da)
- Retention offset from the main peak
- -0.62 min on RG-2
- Mass difference
- +18.011 Da
- Reported in
- 135 of 136 records (99 %)
- Level when reported
- median 0.35 %, max 2.10 %
- Resolution requirement
- Baseline-resolved on the reference method.
maleimide dimer
- Retention offset from the main peak
- +2.42 min on RG-2
- Mass difference
- +3644.975 Da
- Reported in
- 130 of 136 records (96 %)
- Level when reported
- median 0.15 %, max 1.71 %
- Resolution requirement
- Baseline-resolved on the reference method.
mod-GRF (1-29) (−279 Da)
- Retention offset from the main peak
- -1.76 min on RG-2
- Mass difference
- -279.235 Da
- Reported in
- 128 of 136 records (94 %)
- Level when reported
- median 0.23 %, max 1.38 %
- Resolution requirement
- Baseline-resolved on the reference method.
deamidated (+1 Da)
- Retention offset from the main peak
- -0.26 min on RG-2
- Mass difference
- +0.984 Da
- Reported in
- 127 of 136 records (93 %)
- Level when reported
- median 0.16 %, max 1.53 %
- Resolution requirement
- Close-eluting — resolution below 1.2 is common and the peaks merge on short gradients.
Degradation pathways
Degradants are a handling finding rather than a synthesis finding. A lot that shipped clean and arrived oxidised tells you about the courier, not the chemist.
- maleimide ring hydrolysis to the unreactive maleamic acid — the defining stability problem
- this hydrolysis is pH-driven and fast above pH 8